Figure 3.

Gross and histopathology of lungs in chickens and ducks infected with H5N6 viruses. Representative gross lung (left column) and corresponding histological [H&E staining; middle column (A–F)] and immunohistochemical [right column (G–L)] lung sections are shown. Control groups of chickens and ducks inoculated with PBS (A,G); JA1 and SH1 infections in chickens caused severe pneumonia with hemorrhage, inflammatory cell infiltrates, and pulmonary edema (B,C); JA1 and SH1 infections in ducks, respectively, produced obvious and mild pneumonia (D,E). Extensive localization of viral NP to pulmonary capillary, lymphocytes, and vascular endothelial cells for both viruses (H–K).