Table 2.
Sensitivities of methylated KCNQ5 and methylated C9orf50 in stool DNA for detecting colorectal cancer (CRC) in different genders, age groups, stages, tumor locations, tumor sizes, and differentiation statuses.
| KCNQ5 | C9orf50 | KCNQ5 + C9orf50 | ||||
|---|---|---|---|---|---|---|
| Sensitivity (%) | p-value | Sensitivity (%) | p-value | Sensitivity (%) | p-value | |
| Gender | ||||||
| Male (n=120) | 80.0 | 0.256 | 86.7 | 0.686 | 89.2 | 0.670 |
| Female (n=78) | 73.1 | 84.6 | 87.2 | |||
| Age | ||||||
| <40 (n=10) | 90.0 | 0.132 | 80.0 | 0.981 | 90.0 | 0.750 |
| 40–49 (n=20) | 80.0 | 85.0 | 85.0 | |||
| 50–59 (n=54) | 66.7 | 85.2 | 85.2 | |||
| 60–69 (n=57) | 77.2 | 86.0 | 87.7 | |||
| 70–79 (n=44) | 79.5 | 86.4 | 90.9 | |||
| ≥80 (n=13) | 100.0 | 92.3 | 100.0 | |||
| T stage | ||||||
| Tis (n=5) | 60.0 | 0.706 | 60.0 | 0.271 | 80.0 | 0.298 |
| T1 (n=5) | 80.0 | 80.0 | 80.0 | |||
| T2 (n=41) | 75.6 | 85.4 | 85.4 | |||
| T3 (n=89) | 79.8 | 89.9 | 93.3 | |||
| T4 (n=25) | 68.0 | 80.0 | 80.0 | |||
| N/A (n=33) | 81.8 | 84.8 | 87.9 | |||
| N stage | ||||||
| N0 (n=100) | 81.0 | 0.053 | 87.0 | 0.522 | 89.0 | 0.322 |
| N1 (n=43) | 62.8 | 81.4 | 83.7 | |||
| N2 (n=22) | 81.8 | 90.9 | 95.5 | |||
| N/A (n=33) | 81.8 | 84.8 | 87.9 | |||
| Location | ||||||
| Colon (n=78) | 70.5 | 0.109 | 76.9 | 0.006 | 80.8 | 0.011 |
| Rectum (n=113) | 80.5 | 91.2 | 92.9 | |||
| N/A (n=7) | 100.0 | 100.0 | 100.0 | |||
| Size | ||||||
| ≤4 cm (n=89) | 76.4 | 0.952 | 86.5 | 0.828 | 88.8 | 0.879 |
| >4 cm (n=75) | 76.0 | 85.3 | 88.0 | |||
| N/A (n=34) | 82.4 | 85.3 | 88.2 | |||
| Differentiation | ||||||
| Low (n=25) | 76.0 | 0.785 | 92.0 | 0.655 | 92.0 | 0.542 |
| Moderate (n=100) | 79.0 | 86.0 | 89.0 | |||
| High (n=29) | 72.4 | 82.8 | 82.8 | |||
| N/A (n=44) | 77.3 | 84.1 | 88.6 | |||
p-values were calculated by Pearson chi-square test. N/A group data were not included for chi-square test.