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. 2021 Jan 29;11:606656. doi: 10.3389/fphar.2020.606656

FIGURE 1.

FIGURE 1

Location of cholinergic neurons and their projections in the rodent brain. Cholinergic neurons exist in eight distinct clusters labeled Ch1-Ch8. Ch1 and Ch2 are located in the medial septum and the diagonal band of Broca and send projections to the hippocampus (HiF), medial cortex, and thalamic nuclei (Th). The Ch3 cluster is in the diagonal band of Broca with projections to the olfactory bulb (OB). Ch4 neurons are in the nucleus basalis magnocellularis contains, which project to the cortex (CTX) and the amygdala (Amg). Ch5 and Ch6 are in the pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus, respectively, which project to the thalamus (Th), pontine reticular formation, ventral midbrain, ventral tegmental area and to the substantia nigra. Ch7 neurons are in the habenula with projections to the interpeduncular nucleus (IPN). Ch8 are in the parabigeminal nucleus that project to the superior colliculus (Sc) (Thiele 2013; Li et al., 2018).