. 2021 Mar 5;31(3):172–179. doi: 10.2188/jea.JE20190296

Table 2. Eleven identified SNPs associated with any of the BMI phenotypes.

SNP	Chr.^a	Position (bp)^a	REF/ALT	Effect allele frequency^b	Genotyped	Imputation quality score	Candidate gene(s)	Current BMI			BMI at 20			BMI change			Consistency for former reports^g

								Adjusted^d			Adjusted^e			Adjusted^f

								β^b	SE	P-value^c	β^b	SE	P-value^c	β^b	SE	P-value^c
rs939584	2	621558	C/T	0.898	+	1.000	LOC105373352, TMEM18	−0.220	0.067	1.07E-03	−0.217	0.051	2.03E-05	−0.003	0.002	1.52E-01	−
rs13021737	2	632348	A/G	0.898	−	0.993	LOC105373352, TMEM18	−0.214	0.067	1.48E-03	−0.208	0.051	4.02E-05	−0.003	0.002	1.77E-01	−
rs4854349	2	647861	T/C	0.895	−	0.996	LOC105373352, TMEM18	−0.191	0.067	4.26E-03	−0.190	0.051	1.66E-04	−0.002	0.002	2.30E-01	−
rs4409766	10	104616663	T/C	0.295	−	0.996	BORCS7-ASMT	0.181	0.045	4.96E-05	0.036	0.034	2.93E-01	0.005	0.001	1.38E-04	+
rs11030100	11	27677586	G/T	0.403	−	0.963	BDNF-AS	−0.199	0.042	1.68E-06	−0.082	0.031	8.95E-03	−0.005	−0.003	1.96E-04	+
rs6265	11	27679916	C/T	0.403	−	0.996	BDNF	−0.203	0.041	1.00E-06	−0.071	0.031	2.26E-02	−0.005	0.001	5.15E-05	+
rs11030104	11	27684517	A/G	0.402	−	0.963	BDNF-AS	−0.203	0.042	1.01E-06	−0.067	0.031	3.18E-02	−0.005	0.001	3.51E-05	Not shown^H
rs1927790	13	96922191	T/C	0.420	+	1.000	HS6ST3	0.057	0.041	1.64E-01	0.119	0.031	1.39E-04	0.000	0.001	8.34E-01	+
rs1421085	16	53800954	T/C	0.196	−	0.993	FTO	0.335	0.051	1.24E-10	0.173	0.039	8.02E-06	0.007	0.002	2.04E-05	+
rs11642015	16	53802494	C/T	0.196	−	0.963	FTO	0.334	0.051	7.36E-11	0.174	0.039	8.41E-06	0.007	0.002	1.08E-05	+
rs1558902	16	53803574	T/A	0.195	−	0.993	FTO	0.331	0.051	8.65E-11	0.174	0.039	7.69E-06	0.006	0.002	1.59E-05	+

ALT, alternative allele; BMI, body mass index; bp, base pair; Chr., chromosome; REF, reference allele; SE, standard error; SNP, single nucleotide polymorphism.

^aPositions are based on Human Genome version 19 (hg19), build 37.

^bAlternative alleles were treated as effect alleles.

^cSignificant P-values (P ≤ 1.77E-04) are shown in bold.

^dAdjusted model in current BMI were adjusted for age (continuous), age-squared (continuous), sex (male or female), birth year (continuous), and the first five principal components (continuous).

^eAdjusted model in BMI at 20 were adjusted for sex (male or female), birth year (continuous), and the first five principal components (continuous).

^fAdjusted model in BMI change were adjusted for age (continuous), age-squared (continuous), sex (male or female), birth year (continuous), the first five principal components (continuous), and BMI at 20 (continuous).

^gIf the direction of effect allele in initially extracted BMI-related traits was consistent with that of former reports, “+”, if not, “−” is in the column.

^hThe results of estimates were not shown, but only P-values were shown in former reports.