. 2021 Mar 5;31(3):172–179. doi: 10.2188/jea.JE20190296

Table 3. Eleven identified SNPs associated with any of the BMI phenotypes in never-smokers.

SNP	Chr.^a	Position (bp)^a	REF/ALT	Candidate gene(s)	Current BMI			BMI at 20			BMI change

					Adjusted^d			Adjusted^e			Adjusted^f

					β^b	SE	P-value^c	β^b	SE	P-value^c	β^b	SE	P-value^c
rs939584	2	621558	C/T	LOC105373352, TMEM18	−0.287	0.088	1.03E-03	−0.246	0.065	1.60E-04	−0.006	0.003	3.12E-02
rs13021737	2	632348	A/G	LOC105373352, TMEM18	−0.288	0.087	9.63E-04	−0.254	0.065	9.05E-05	−0.005	0.003	3.40E-02
rs3800229	6	108996963	G/T	FOXO3	−0.254	0.063	5.96E-05	−0.087	0.047	6.37E-02	−0.006	0.002	1.25E-03
rs143665886	7	115368366	T/C	SNORA25B, TFEC	0.037	0.053	4.85E-01	0.151	0.039	1.31E-04	−0.001	0.002	5.27E-01
rs4409766	10	104616663	T/C	BORCS7-ASMT	0.236	0.058	4.26E-05	0.075	0.043	8.11E-02	0.006	0.002	3.72E-04
rs11030100	11	27677586	G/T	BDNF-AS	−0.266	0.054	7.93E-07	−0.117	0.040	3.50E-03	−0.006	0.002	1.77E-04
rs6265	11	27679916	C/T	BDNF	−0.265	0.054	8.14E-07	−0.097	0.040	1.49E-02	−0.006	0.002	8.03E-05
rs11030104	11	27684517	A/G	BDNF-AS	−0.261	0.054	1.14E-06	−0.090	0.040	2.37E-02	−0.006	0.002	6.35E-05
rs1421085	16	53800954	T/C	FTO	0.358	0.067	7.39E-08	0.164	0.050	9.61E-04	0.007	0.002	1.41E-04
rs11642015	16	53802494	C/T	FTO	0.361	0.067	5.74E-08	0.163	0.050	1.00E-03	0.008	0.002	1.07E-04
rs1558902	16	53803574	T/A	FTO	0.365	0.067	4.45E-08	0.164	0.050	9.24E-04	0.008	0.002	9.54E-05

ALT, alternative allele; BMI, body mass index; bp, base pair; Chr., chromosome; REF, reference allele; SE, standard error; SNP, single nucleotide polymorphism.

^aPositions are based on Human Genome version 19 (hg19), build 37.

^bAlternative alleles were treated as effect alleles.

^cSignificant P-values (P ≤ 1.77E-04) are shown in bold.

^dAdjusted model in current BMI were adjusted for age (continuous), age-squared (continuous), sex (male or female), birth year (continuous), and the first five principal components (continuous).

^eAdjusted model in BMI at 20 were adjusted for sex (male or female), birth year (continuous), and the first five principal components (continuous).

^fAdjusted model in BMI change were adjusted for age (continuous), age-squared (continuous), sex (male or female), birth year (continuous), the first five principal components (continuous), and BMI at 20 (continuous).