Table 4. Seven identified SNPs associated with the current BMI adjusted for total energy intake.
SNP | Candidate gene(s) |
Current BMI | |||
Adjusted modela | Adjusted model + total energyd/weighte | ||||
βb | P-valuec | βb | P-valuec | ||
rs4409766 | BORCS7-ASMT | 0.181 | 4.96E-05 | 0.036 | 2.93E-01 |
rs11030100 | BDNF-AS | −0.199 | 1.68E-06 | −0.082 | 8.95E-03 |
rs6265 | BDNF | −0.203 | 1.00E-06 | −0.071 | 2.26E-02 |
rs11030104 | BDNF-AS | −0.203 | 1.01E-06 | −0.067 | 3.18E-02 |
rs1421085 | FTO | 0.335 | 1.24E-10 | 0.174 | 8.02E-06 |
rs11642015 | FTO | 0.334 | 7.36E-11 | 0.173 | 8.41E-06 |
rs1558902 | FTO | 0.331 | 8.65E-11 | 0.174 | 7.69E-06 |
BMI, body mass index; SNP, single nucleotide polymorphism.
aAdjusted models were adjusted for age (continuous), age-squared (continuous), sex (male or female), birth year (continuous), and the top 5 principal components (continuous).
bAlternative alleles were treated as effect alleles.
cSignificant P-values (P ≤ 1.77E-04) are shown in bold.
dTotal energy was estimated using a self-reported food frequency questionnaire.
eWeight indicates self-reported current weight.