Figure 3.

NP Transplant Modulates the Pulmonary Cytokine Microenvironment without Altering the Serum Cytokine Profile

S. aureus pneumonia was induced 48 h after hemorrhagic shock, with or without adoptive transfer of NPs. Concentrations of IL-6, CXCL1, TNFα, IL-1β, IL-10, G-CSF, GM-CSF, and CXCL5 in (A) the serum 24 h after induction of sham pneumonia, (B) the serum 24 h after induction of pneumonia, (C) the lung homogenate 24 h post sham pneumonia, and (D) the lung homogenate 24 h post pneumonia, were measured by cytometric bead array. Data were acquired across at least three independent experiments, with duplicate measures of each sample/cytokine. Data are expressed as means ± SEM. Data were fit to a lognormal distribution, analyzed by GLMs, and the Holms test was used to adjust for multiple comparisons. ^∗p < 0.05, ^∗∗p < 0.01.

See also Figure S4 for the complete dataset that includes mice subjected to sham hemorrhage procedure.