Fig. 7.

The molecular conformation of SF regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface. Applying FN as a model cellular adhesive protein, the surface stability of the SF substrates and the accompanying detachment resistance of adsorbed protein on these SF substrates increased with increasing β-sheet content. Furthermore, more cytoskeleton-associated FAs, higher orders of cytoskeletal organization, and more elongated spreading shapes were observed in the BMSCs cultured on the SFH surface than in those cultured on the SFL surface, along with the enhancement of nuclear translocation and activation of YAP/TAZ and RUNX2 in intracellular mechanotransduction