Table 3.
Summary of analytes with ANOVA and pairwise comparison for urine
| Analyte, pg/pmol | HC | CKD | SSc– CKD | SSc–no CKD | ANOVA | SSc vs SSc–CKD P-value | SSc–CKD vs CKD P-value | SSc–CKD vs HC P-value |
|---|---|---|---|---|---|---|---|---|
| IL6 | ||||||||
| Median | 0.22 | 0.65 | 0.52 | 0.42 | 0.008 | 0.2243 | 0.7273 | 0.0018 |
| Minimum | 0.11 | 0.24 | 0.048 | 0.082 | ||||
| Maximum | 0.46 | 1.9 | 1.5 | 1.3 | ||||
| Mean | 0.23 | 0.69 | 0.57 | 0.47 | ||||
| s.d. | 0.1 | 0.51 | 0.36 | 0.3 | ||||
| MCP1 | ||||||||
| Median | 9.8 | 23 | 23 | 19 | 0.0032 | 0.0868 | 0.5803 | <0.0001 |
| Minimum | 2.2 | 5.9 | 0.81 | 2.1 | ||||
| Maximum | 12 | 54 | 70 | 54 | ||||
| Mean | 8.7 | 26 | 30 | 22 | ||||
| s.d. | 3.4 | 21 | 20 | 15 | ||||
| TNF-α | ||||||||
| Median | 0.15 | 0.4 | 0.38 | 0.38 | 0.0164 | >0.9999 | 0.7162 | 0.004 |
| Minimum | 0.016 | 0.18 | 0.028 | 0.018 | ||||
| Maximum | 0.49 | 0.84 | 1.5 | 1.3 | ||||
| Mean | 0.17 | 0.44 | 0.44 | 0.43 | ||||
| s.d. | 0.16 | 0.21 | 0.34 | 0.3 | ||||
| VEGF | ||||||||
| Median | 31 | 29 | 34 | 36 | 0.9828 | 0.9081 | 0.7654 | 0.739 |
| Minimum | 17 | 19 | 11 | 1.8 | ||||
| Maximum | 52 | 61 | 90 | 129 | ||||
| Mean | 33 | 34 | 38 | 39 | ||||
| s.d. | 10 | 14 | 19 | 27 | ||||
| MCP3 | ||||||||
| Median | 0.84 | 1.6 | 3 | 2 | 0.0101 | 0.4744 | 0.2185 | 0.0008 |
| Minimum | 0 | 0.55 | 0 | 0 | ||||
| Maximum | 2.1 | 3.6 | 10 | 9 | ||||
| Mean | 0.94 | 1.9 | 3.5 | 3 | ||||
| s.d. | 0.64 | 0.95 | 3 | 2.6 | ||||
| IL18 | ||||||||
| Median | 3.9 | 5.7 | 8.9 | 7.9 | 0.0053 | 0.6337 | 0.0493 | 0.0026 |
| Minimum | 1.6 | 2.4 | 1.1 | 1.2 | ||||
| Maximum | 7.4 | 12 | 31 | 29 | ||||
| Mean | 2.2 | 2.9 | 7.1 | 6.8 | ||||
| s.d. | 0.65 | 0.97 | 1.2 | 1.1 | ||||
| ICAM-1 | ||||||||
| Median | 60 | 855 | 968 | 570 | <0.0001 | 0.0134 | 0.7049 | <0.0001 |
| Minimum | 8.8 | 73 | 9 | 13 | ||||
| Maximum | 275 | 3991 | 4678 | 2391 | ||||
| Mean | 94 | 1307 | 1499 | 807 | ||||
| s.d. | 82 | 1211 | 1302 | 704 | ||||
| VCAM-1 | ||||||||
| Median | 382 | 336 | 491 | 342 | 0.4377 | 0.2239 | 0.198 | 0.2928 |
| Minimum | 44 | 40 | 5.2 | 8.1 | ||||
| Maximum | 735 | 857 | 2371 | 1435 | ||||
| Mean | 400 | 387 | 704 | 509 | ||||
| s.d. | 207 | 294 | 632 | 450 |
CKD: chronic kidney disease; HC: healthy control; MCP1: monocyte chemoattractant protein 1; MCP2: monocyte chemoattractant protein 2; VCAM-1: vascular cell adhesion molecule 1; ICAM-1: intercellular adhesion molecule 1.