Table 4.

Cancer susceptibility conditions with the highest fraction of affected individuals in the cohort.

Cancer susceptibility syndromes	Gene	Allele freq.
Hereditary cancer-predisposing syndrome	CHEK2 + RAD51	0.58%
Juvenile polyposis syndrome	SMAD4	0.44%
Adenomatous polyposis coli	APC	0.42%
Breast-ovarian cancer, familial 1	BRCA1	0.41%
Li-Fraumeni syndrome 1	TP53	0.40%
Lynch syndrome	MSH6	0.40%
MYH-associated polyposis	MUTYH	0.40%
Neuroblastoma	KIF1B	0.40%
PTEN hamartoma tumor syndrome	PTEN	0.40%
Prostate cancer	EHBP1	0.40%
Breast-ovarian cancer, familial 2	BRCA2	0.29%