Table 2.
Signal detection for AKI and CKD of PPIs users from FAERS database.
| Renal injury | Drugs | Cases with renal injury/n | Cases with all AE/N | Proportion of renal injury cases in all AE cases/% | ROR | 95% CI |
|---|---|---|---|---|---|---|
| AKI | All PPIs | 3187 | 35,251 | 9.04 | 3.95 | 3.81–4.10 |
| Omeprazole | 561 | 10,299 | 5.45 | 2.25 | 2.07–2.45 | |
| Pantoprazole | 999 | 8963 | 11.15 | 4.92 | 4.61–5.26 | |
| Lansoprazole | 1014 | 6093 | 16.64 | 7.84 | 7.33–8.39 | |
| Rabeprazole | 55 | 1439 | 3.82 | 1.55 | 1.18–2.03 | |
| Esomeprazole | 353 | 7273 | 4.85 | 1.99 | 1.79–2.22 | |
| Dexlansoprazole | 205 | 1184 | 17.31 | 8.18 | 7.04–9.51 | |
| CKD | All PPIs | 3457 | 35,251 | 9.81 | 8.80 | 8.49–9.13 |
| Omeprazole | 166 | 10,299 | 1.61 | 1.27 | 1.09–1.48 | |
| Pantoprazole | 1196 | 8963 | 13.34 | 12.11 | 11.39–12.87 | |
| Lansoprazole | 1542 | 6093 | 25.31 | 26.80 | 25.28–28.40 | |
| Rabeprazole | 28 | 1439 | 1.95 | 1.54 | 1.06–2.23 | |
| Esomeprazole | 158 | 7273 | 2.17 | 1.72 | 1.47–2.01 | |
| Dexlansoprazole | 367 | 1184 | 31.00 | 34.94 | 30.89–39.53 |
PPIs proton pump inhibitors, AKI acute kidney injury, CKD chronic kidney disease, AE adverse event, ROR reporting odds ratio, 95% CI 95% confidence interval.