Table 1.
Characteristics of TEDDY children with islet autoimmunity and control children.
| Case children Total n = 398 |
Control children Total n = 1178 |
|
|---|---|---|
| Clinical center, n (%) | ||
| Colorado | 56 (14.1) | 162 (13.8) |
| Georgia | 27 (6.8) | 78 (6.6) |
| Washington | 36 (9.1) | 107 (9.1) |
| Finland | 113 (28.4) | 339 (28.8) |
| Germany | 35 (8.8) | 105 (8.9) |
| Sweden | 131 (32.9) | 387 (32.9) |
| Sex, n (%) | ||
| Female | 178 (44.7) | 530 (45.0) |
| Male | 220 (55.3) | 648 (55.0) |
| Status regarding first degree relative | ||
| First degree relative with type 1 diabetes | 88 (22.1) | 259 (22.0) |
| General population | 310 (77.9) | 917 (78.0) |
| HLA genotype, n (%) | ||
| High risk (DR3/4) | 210 (52.8) | 420 (35.7) |
| Moderate risk (other genotypes) | 187 (47.0) | 747 (63.4) |
| Missing | 1 (0.2) | 11 (0.9) |
| Ancestry, mean (SD) | ||
| Principal component 1 | 0.0017 (0.0074) | 0.0013 (0.0078) |
| Principal component 2 | − 0.0003 (0.0109) | − 0.0016 (0.0094) |
| Breastfed, n (%) | ||
| At 3 months | 307 (77.1) | 903 (76.7) |
| At 6 months | 252 (63.3) | 778 (66.0) |
| Missing information | 1 (0.3) | 4 (0.3) |
| Weight z score, mean (SD) | ||
| At 3 months | 0.68 (0.95) | 0.41 (1.03) |
| At 6 months | 0.47 (1.00) | 0.24 (1.01) |
| Over 1–6 years | 0.20 (1.04) | 0.01 (0.99) |