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. 2021 Feb 11;11:3639. doi: 10.1038/s41598-021-83058-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distributions of URDVs Identified by WES. (a) Chart shows count of URDVs in NTD candidate gene(s) identified per exome of MM subjects varied from 0 to 8. In this study, the number of EA MMC subjects is 254 and the number of MA MMC subjects is 252. Approximately 25–30% subjects had no URDVs in NTD candidate genes, around 35% had one URDV, and the remaining had more than one. (b) Shows counts of URDVs discovered per NTD candidate gene ranged from one to nine with nearly 65% genes containing only one. Total number of URDV-containing NTD candidate genes found in EA and MA MMC subjects are 202 and 203 respectively.