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. 2021 Feb 11;11:3639. doi: 10.1038/s41598-021-83058-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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URDV containing candidate genes involved in multiple ontology groups. The Venn diagrams showed the relation and distribution of UTDV count and NTD candidate genes count to five ontology groups for EA (a) and MA (b). The number of URDVs and number of genes classified to cilium, WNT signaling, cytoskeleton, extracellular matrix (ECM) and cell migration are shown as fraction (count of URDV/count of gene). Genes classified to multiple categories were shown in the overlapped subset compartments between categories. Details on genes within each segment can be found in Supplementary Table 5.