Fig. 4.

Insulin sensitivity modulates the NASH-associated increase in plasma BA in the combined cohort (n = 239).

(A) Plasma total CA concentrations (nmol/L) according to HOMA2S (%). (B) Plasma total CA concentrations (nmol/L) according to HOMA2B (%). White circles represent the No-NASH and black circles the NASH patients. Dashed lines: regression curves for No-NASH patients; solid lines: regression curves for NASH patients. Rho coefficients and p values were obtained using the Spearman Rank test. BA, bile acids; CA, cholic acid; HOMA, homeostatic model assessment; NASH, non-alcoholic steatohepatitis.