Figure 7.

Rituximab induces NOTCH1 signaling more strongly than obinutuzumab

(A) HES1 (left) and CCL4 (right) expression in SU-DHL4 cells after 150 min of treatment with 2.5 μg/ml rituximab (R) or obinutuzumab (O) relative to untreated controls (Ctrl). Mean with range is plotted.

(B) Calculated AUCs for phosphopeptide ions containing the phosphorylation site Ser⁷⁹¹ on ADAM17. Line indicates mean. ∗p<0.05, ∗∗p<0.01, ∗∗∗p<0.001, ∗∗∗∗p<0.0001ns = not significant, as calculated by unpaired non-parametric t tests.