Figure S5.

CompBio analysis comparing COV2-2050 D+2, isotype control, and COV2-2050 LALA-PG D+2, related to Figure 5

(A) Three-dimensional map from principal component analysis (PCA) of the RNA-seq data in the study. The PCA was performed using 12,157 unique genes with counts per million reads ≥ 1 in at least 5 of the study samples (n = 31). Each mouse is represented by an individual point that is color-matched to its corresponding experimental group and connected to the centroid point (with a cross bar and ID number) of the corresponding group. (B) Heatmaps of selected relevant biological themes enriched in COV2-2050 D+2 versus isotype control and COV2- LALA-PG D+2. Genes shown are common in the pair of comparisons with an enrichment score of 100 or greater in either of the paired comparisons.