TABLE 4.
Rates of transfusion-related adverse reactions per 100,000 total units (full and aliquot) transfused,* by component type, collection method, irradiation, and leukoreduction as reported to the NHSN Hemovigilance Module, United States, 2010 to 2012†
| Transfused blood components | Total adverse reactions‡§ | Allergic | FNHTR | DSTR | TACO‖ | Hypotensive | DHTR | TAD | TRALI | AHTR | TTI | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All components | ||||||||||||||||||||||
| All adverse reactions | 5136 | (239.5) | 2406 | (112.2) | 1853 | (86.4) | 321 | (15.0) | 196 | (9.1) | 136 | (6.3) | 90 | (4.2) | 72 | (3.4) | 26 | (1.2) | 24 | (1.1) | 12 | (0.6) |
| Severe, life-threatening, and fatal adverse reactions | 376 | (17.5) | 172 | (8.0) | 18 | (0.8) | 3 | (0.1) | 72 | (3.4) | 34 | (1.6) | 17 | (0.8) | 17 | (0.8) | 22 | (1.0) | 12 | (0.6) | 9 | (0.4) |
| RBCs | ||||||||||||||||||||||
| All units | 2519 | (205.5) | 657 | (53.6) | 1303 | (106.3) | 309 | (25.2) | 75 | (6.1) | 85 | (6.9) | 49 | (4.0) | 18 | (1.5) | 19 | (1.6) | 4 | (0.3) | ||
| Collection method | ||||||||||||||||||||||
| Apheresis | 253 | (243.9) | 63 | (60.7) | 130 | (125.3) | 28 | (27.0) | 11 | (10.6) | 17 | (16.4) | 4 | (3.9) | 0 | (0) | 0 | (0) | 0 | (0) | ||
| Whole blood derived | 2236 | (199.3) | 590 | (52.6) | 1167 | (104.0) | 268 | (23.9) | 64 | (5.7) | 65 | (5.8) | 45 | (4.0) | 16 | (1.4) | 18 | (1.6) | 3 | (0.3) | ||
| Irradiation | ||||||||||||||||||||||
| Irradiated | 610 | (200.2) | 184 | (60.4) | 339 | (111.3) | 41 | (13.5) | 18 | (5.9) | 10 | (3.3) | 10 | (3.3) | 3 | (1.0) | 3 | (1.0) | 2 | (0.7) | ||
| Not irradiated | 1902 | (206.5) | 471 | (51.1) | 964 | (104.7) | 264 | (28.7) | 57 | (6.2) | 74 | (8.0) | 39 | (4.2) | 15 | (1.6) | 16 | (1.7) | 2 | (0.2) | ||
| Leukoreduction | ||||||||||||||||||||||
| Leukoreduced | 2389 | (205.1) | 638 | (54.8) | 1225 | (105.2) | 296 | (25.4) | 71 | (6.1) | 72 | (6.2) | 47 | (4.0) | 18 | (1.5) | 18 | (1.5) | 4 | (0.3) | ||
| Not leukoreduced | 127 | (208.8) | 19 | (31.2) | 78 | (128.2) | 12 | (19.7) | 4 | (6.6) | 11 | (18.1) | 2 | (3.3) | 0 | (0) | 1 | (1.6) | 0 | (0) | ||
| PLTs | ||||||||||||||||||||||
| All units | 1659 | (421.7) | 1188 | (302.0) | 404 | (102.7) | 4 | (1.0) | 28 | (7.1) | 3 | (0.8) | 16 | (4.1) | 4 | (1.0) | 5 | (1.3) | 7 | (1.8) | ||
| Collection method | ||||||||||||||||||||||
| Apheresis | 1547 | (537.6) | 1134 | (394.1) | 358 | (124.4) | 3 | (1.0) | 25 | (8.7) | 3 | (1.0) | 12 | (4.2) | 3 | (1.0) | 4 | (1.4) | 5 | (1.7) | ||
| Whole blood derived | 107 | (101.3) | 52 | (49.2) | 44 | (41.7) | 0 | (0) | 3 | (2.8) | 0 | (0) | 4 | (3.8) | 1 | (0.9) | 1 | (0.9) | 2 | (1.9) | ||
| Irradiation | ||||||||||||||||||||||
| Irradiated | 876 | (289.6) | 604 | (199.7) | 231 | (76.4) | 3 | (1.0) | 15 | (5.0) | 0 | (0) | 14 | (4.6) | 3 | (1.0) | 2 | (0.7) | 4 | (1.3) | ||
| Not irradiated | 782 | (860.3) | 584 | (642.4) | 172 | (189.2) | 1 | (1.1) | 13 | (14.3) | 3 | (3.3) | 2 | (2.2) | 1 | (1.1) | 3 | (3.3) | 3 | (3.3) | ||
| Leukoreduction | ||||||||||||||||||||||
| Leukoreduced | 1643 | (430.9) | 1179 | (309.2) | 398 | (104.4) | 4 | (1.0) | 28 | (7.3) | 2 | (0.5) | 16 | (4.2) | 4 | (1.0) | 5 | (1.3) | 7 | (1.8) | ||
| Not leukoreduced | 15 | (124.5) | 9 | (74.7) | 5 | (41.5) | 0 | (0) | 0 | (0) | 1 | (8.3) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | ||
| Plasma | ||||||||||||||||||||||
| All units | 511 | (127.7) | 423 | (105.7) | 58 | (14.5) | 0 | (0) | 23 | (5.7) | 0 | (0) | 4 | (1.0) | 3 | (0.7) | 0 | (0) | 0 | (0) | ||
| Collection method | ||||||||||||||||||||||
| Apheresis | 44 | (145.7) | 36 | (119.2) | 4 | (13.2) | 0 | (0) | 4 | (13.2) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | ||
| Whole blood derived | 457 | (123.5) | 379 | (102.4) | 54 | (14.6) | 0 | (0) | 18 | (4.9) | 0 | (0) | 3 | (0.8) | 3 | (0.8) | 0 | (0) | 0 | (0) | ||
| Cryoprecipitate | ||||||||||||||||||||||
| All units | 7 | (5.6) | 6 | (4.8) | 1 | (0.8) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | 0 | (0) | ||
Rates are based on total components transfused as reported by included facilities for 2010-2012.
Data are reported as number (rate).
Adverse reactions that met definite or probable case definition and definite, probable, or possible imputability criteria as reported by 77 health care facilities included in this analysis.
Adverse reactions for which a specific component type was not reported (244 reactions) are included in rate calculations for all components.
Circulatory overload is not reported as due to a specific component type per NHSN Hemovigilance Module protocol.
AHTR = acute hemolytic transfusion reaction; DHTR = delayed hemolytic transfusion reaction; DSTR = delayed serologic transfusion reaction; FNHTR = febrile nonhemolytic transfusion reaction; TACO = transfusion-associated circulatory overload; TAD = transfusion-associated dyspnea; TRALI = transfusion-related acute lung injury; TTI = transfusion-transmitted infection.