Figure 1.

(a) Light microscopy shows a proliferative glomerulonephritis. (i-iii) Glomeruli show endocapillary and mesangial hypercellularity, lobular accentuation of the glomerular capillary tufts, double contour formation along the capillary walls, and wire loop-type and immune microthrombi (arrows) (hematoxylin and eosin, original magnification ×40). (Immunofluorescence microscopy shows bright staining for all immunoglobulins and complement proteins. Immunofluorescence studies showing bright 3+ granular staining for IgG, IgA, IgM, C1q, C3, C4d, and kappa and lambda light chains (periodic acid–Schiff, original magnification ×40). (c) Electron microscopy shows numerous mesangial and capillary wall electron dense deposits (silver methenamine). (i) Mesangial and subendothelial electron dense deposits are both present (original magnification × 3000). (ii–iii) Large subendothelial electron-dense deposits line the capillary walls (original magnification ×6000).