Table 2.
Nutritional, metabolic, inflammatory, muscle mass, residual kidney function, and peritoneal clearance variables by serum Kprior-4mo
| Serum Kprior-4mo, mEq/l |
|||||
|---|---|---|---|---|---|
| <3.5 | 3.5–3.9 | 4.0–4.4 | 4.5–4.9 | ≥5.0 | |
| Patients, n | 823 | 2019 | 2368 | 1555 | 656 |
| Nutritional, mean (SD) | |||||
| Body mass index, kg/m2 | 24.6 (5.7) | 27.3 (6.2) | 27.7 (6.3) | 27.5 (6.0) | 28.2 (6.2) |
| Serum bicarbonate, mEq/l | 27.1 (3.5) | 26.1 (3.3) | 25.3 (3.3) | 24.5 (3.4) | 23.7 (3.5) |
| Serum phosphorus, mg/dl | 4.27 (1.44) | 4.78 (1.36) | 5.13 (1.40) | 5.44 (1.47) | 5.97 (1.68) |
| Serum magnesium, mg/dl | 1.96 (0.51) | 2.06 (0.42) | 2.15 (0.47) | 2.23 (0.49) | 2.27 (0.49) |
| Serum albumin, g/dl | 3.19 (0.70) | 3.39 (0.56) | 3.43 (0.57) | 3.48 (0.54) | 3.51 (0.51) |
| Body weight, kg | 65.5 (19.1) | 76.1 (21.3) | 78.4 (21.7) | 78.5 (20.9) | 80.4 (21.9) |
| Serum urea, mg/dl | 86 (401) | 105 (326) | 128 (515) | 154 (635) | 267 (1032) |
| Metabolic, mean (SD) | |||||
| Glucose, mg/dl | 144 (76) | 144 (78) | 141 (73) | 138 (75) | 134 (68) |
| Total cholesterol, mg/dl | 178 (51) | 172 (48) | 176 (51) | 175 (47) | 170 (43) |
| Triglycerides, mg/dl | 175 (121) | 175 (106) | 181 (132) | 163 (103) | 160 (94) |
| HbA1C for diabetic patients, % | 7.20 (1.63) | 7.44 (3.32) | 7.06 (1.54) | 7.09 (3.39) | 6.99 (1.53) |
| Uric acid, mg/dl | 6.38 (1.78) | 6.23 (1.66) | 6.14 (1.48) | 6.17 (1.45) | 6.07 (1.44) |
| Inflammatory, median (IQR) | |||||
| C-reactive protein,a mg/dl | 0.40 (0.11–1.20) | 0.33 (0.14–0.95) | 0.30 (0.11–0.83) | 0.25 (0.10–0.60) | 0.30 (0.10–0.80) |
| Muscle mass, mean (SD) | |||||
| Creatinine generation rate,b g/d per 1.73 m2 | 13.1 (19.9) | 16.4 (20.9) | 19.3 (20.7) | 21.8 (23.9) | 20.9 (22.1) |
| Serum creatinine, mg/dl | 8.08 (3.56) | 8.11 (3.70) | 8.50 (3.92) | 9.15 (4.12) | 9.67 (4.16) |
| RKF, peritoneal clearance, and membrane function | |||||
| Peritoneal creatinine clearance, liter/week, mean (SD) | 49.6 (26.8) | 46.1 (28.0) | 45.2 (33.3) | 41.6 (30.1) | 42.6 (28.4) |
| rGFR, ml/min per 1.73 m2, mean (SD) | 2.29 (3.41) | 2.76 (3.73) | 3.15 (3.75) | 3.36 (4.00) | 2.72 (3.49) |
| 24-h urine volume, liters, mean (SD) | 0.59 (0.65) | 0.73 (0.69) | 0.91 (0.75) | 1.00 (0.82) | 0.99 (0.83) |
| Total Kt/V urea, mean (SD) | 2.21 (0.78) | 2.31 (0.72) | 2.33 (0.69) | 2.24 (0.70) | 2.20 (0.72) |
| Peritoneal Kt/V urea, mean (SD) | 1.59 (0.57) | 1.52 (0.55) | 1.41 (0.50) | 1.35 (0.52) | 1.37 (0.57) |
| PSTR, mean (SD) | 0.70 (0.13) | 0.67 (0.14) | 0.68 (0.14) | 0.68 (0.14) | 0.68 (0.14) |
| Net 24-h peritoneal ultrafiltration, ml, median (IQR) | 700 (200–1191) | 746 (312–1394) | 719 (250–1229) | 700 (201–1286) | 748 (286–1510) |
| 24-h urine volume plus net 24-hr ultrafiltration, liters, median (IQR) | 1.25 (0.80–1.78) | 1.50 (0.95–2.18) | 1.65 (1.10–2.27) | 1.75 (1.23–2.36) | 1.90 (1.30–2.58) |
HbA1C, glycosylated hemoglobin; IQR, interquartile ratio; Kprior-4mo, average monthly serum potassium measured during the 4 months before study enrollment; PSTR, peritoneal solute transport rate (dialysate/plasma creatinine ratio at 4 hrs); rGFR, residual glomerular filtration rate (mean of the urinary creatinine and the urea clearance); RKF, residual kidney function; SD, standard deviation.
a
Rarely measured in Canada, Thailand, and the United States.
b
Calculation of the total creatinine mass removed.