Figure 2.

Analysis of the pharmacokinetic/pharmacodynamic relationship between aminoglycoside concentration and bacterial killing for KPC-Kp with (green) and without (blue) aac(6’)-Ib in time–kill experiments. Bacterial reduction at 24 h versus aminoglycoside concentration (a–c) and concentrations normalized by aminoglycoside MICs (d–f) were fit to Hill-type functions (lines). EC₅₀ and r² values corresponding to parameters from the Hill-type functions from the MIC normalized fits (d–f) appear below each panel.