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Pharmacodynamic effects of human simulated pharmacokinetics for amikacin (a), gentamicin (b) and tobramycin (c) against KPC-Kp with aac(6’)-Ib (green) and without aac(6’)-Ib (blue) in the one-compartment pharmacokinetic/pharmacodynamic model over 72 h. Each line represents the mean of two duplicate experiments. The LLQ for bacterial density was 250 cfu/mL. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.
