Table 2.
Susceptibility of envelopes to temsavir based on the indicated IC50s
| Subtype | # | IC50 <1 nM (%) | IC50 >1 to <10 nM (%) | IC50 >10 to <100 nM (%) | IC50 >100 nM (%) | Geometric mean IC50 (nM)a | Median IC50 (nM)a | 90th percentile IC50 (nM)a |
|---|---|---|---|---|---|---|---|---|
| All | 1337 | 719 (53.8) | 352 (26.3) | 146 (10.9) | 120 (9.0) | 1.7 | 0.8 | 75.4 |
| B | 881 | 544 (61.7) | 196 (22.2) | 85 (9.6) | 56 (6.4) | 1.2 | 0.6 | 47.6 |
| C | 156 | 78 (50.0) | 56 (35.9) | 15 (9.6) | 7 (4.5) | 1.5 | 1.0 | 22.9 |
| A1 | 17 | 5 (29.4) | 11 (64.7) | 0 (0) | 1 (5.9) | 1.8 | 1.8 | 4.3 |
| A | 43 | 10 (23.3) | 21 (48.8) | 8 (18.6) | 4 (9.3) | 3.8 | 2.3 | 57.7 |
| BF | 19 | 5 (26.3) | 8 (42.1) | 2 (10.5) | 4 (21.1) | 4.6 | 1.3 | 190.4 |
| F1 | 48 | 8 (16.7) | 15 (31.3) | 13 (27.1) | 12 (25.0) | 17.9 | 13.8 | 892.9 |
| B, F1 | 29 | 4 (13.8) | 9 (31.0) | 5 (17.2) | 11 (37.9) | 38.4 | 12.7 | 6925.3 |
| CRF01_AE | 5 | 0 (0) | 0 (0) | 0 (0) | 5 (100) | – | – | – |
a
May include isolates with >MAX IC50 (MAX = 5000 nM or >100 nM IC50).