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Susceptibility of envelopes to temsavir based upon envelope tropism
| Tropism | # | IC50 ≤1 nM (%) | IC50 >1 to ≤10 nM (%) | IC50 >10 to ≤100 nM (%) | IC50 >100 nM (%) | Geometric mean (nM)a |
|---|---|---|---|---|---|---|
| All | 607 | 315 (51.9) | 148 (24.4) | 75 (12.4) | 69 (11.4) | 2.25 |
| CXCR4 | 43 | 21 (48.8) | 9 (20.9) | 8 (18.6) | 5 (11.6) | 2.94 |
| CCR5 | 225 | 109 (48.4) | 54 (24.0) | 33 (14.7) | 29 (12.9) | 2.77 |
| Dual mixed | 339 | 185 (54.6) | 85 (25.1) | 34 (10.0) | 35 (10.3) | 1.89 |
May include isolates with >MAX IC50 (MAX = 5000 nM).
