. 2020 Nov 23;76(3):680–683. doi: 10.1093/jac/dkaa487

Table 1.

Efficacy of imipenem and meropenem, alone and in combination, in the experimental peritoneal sepsis models with carbapenem-resistant A. baumannii isolates

Isolate	Treatment group	n	Doses (mg/kg)	Spleen (log₁₀ cfu/g)	Blood (log₁₀ cfu/mL)	Bacteraemia (%)	Mortality (%)
OXA-58	Control	15	–	8.97 ± 0.72	7.39 ± 2.23	93	36
	IPM	15	30	5.55 ± 1.94^a	3.86 ± 2.85^a	87	7
	MEM	15	300	1.93 ± 2.59^a^,^b	0.46 ± 0.93^a^,^b	27^a^,^b	0^a
	IPM+MEM	15		1.73 ± 2.26^a^,^b	0.23 ± 0.64^a^,^b	13^a^,^b	0^a
OXA-23	Control	15	–	8.96 ± 1.13	5.55 ± 1.94	100	79
	IPM	15	30	8.12 ± 0.53^a	6.56 ± 1.10	100	67
	MEM	15	300	5.44 ± 0.74^a	3.84 ± 0.98^a^,^b	100	27^a^,^b
	IMP+MEM	15		4.66 ± 1.66^a^,^b	1.59 ± 0.99^a^,^b^,^c	80	13^a^,^b

Control received no antimicrobial treatment; IPM, imipenem; MEM, meropenem.

P ≤ 0.05 with respect to Control group.

P ≤ 0.05 with respect to IPM group.

P ≤ 0.05 with respect to MEM group.