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. 2021 Feb 12;19:21. doi: 10.1186/s12958-021-00701-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — miRNA-4497 induced trophoblast apoptosis by targeting SP1. (a) Effect of miRNA-4497 on trophoblast cell apoptosis was detected by apoptosis assay. miRNA-4497 overexpression significantly induced trophoblasts apoptosis. (b) Western blotting was used to detect the effect of SP1-siRNA on the expression of SP1. Transfection of SP1-siRNA into trophoblast significantly reduced the SP1 protein expression. (c) Effect of SP1 on trophoblasts apoptosis was detected by apoptosis assay. SP1 under-expression led to an increased percentage of apoptotic cells in HTR-8/SVneo culture. *, P<0.05; ***, P<0.001