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. 2021 Feb 12;9:24. doi: 10.1186/s40478-020-01115-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Volumetric increase of GBM vasculature and heterogeneity is due to increased calibers and primary branching. a Creation of COL-IV isosurfaces in normal CTX and GBM. b Volumetric surface increases in GBM. c Measurements of diameter of COL-IV⁺ vessels in normal CTX (N. CTX) and GBM. d Quantifications of diameters in GBM compared to normal CTX. e, f and g Alpha blending of primary, secondary and tertiary branching points. h Percentage of branching types (single and multiple) in normal CTX and GBM. i Representative image of isosurface rendering and quantification of branching points. j Quantification of primary, secondary and tertiary branching points. k Representative images of branching points in GBM from primary to tertiary (top panel), and looping, intussusception and silent collateral vessels (bottom panel, from left to right respectively). l Quantification of silent collateral BV in normal and GBM