Table 1.

Known interactions between viruses and NHEJ components

Baltimore classification	Virus	Abbreviation	Interaction with NHEJ components
Group I: dsDNA viruses	Adenovirus	ADV	DNA-PKcs [15, 18, 21], Lig4 [16], XRCC4 [17], Ku70 [20]
	Epstein Barr virus	EBV	Ku80 [24], DNA-PKcs [29]
	Herpes simplex virus 1	HSV-1	DNA-PKcs [10, 34, 37, 39], Ku80 [38], Ku70 [39], Lig4/XRCC4 [40], PAXX [42],
	Human papillomavirus	HPV	Ku70/80 [45, 46]
	John Cunningham virus	JC virus	Ku70/80 [47]
	Kaposi sarcoma-associated herpesvirus	KSHV	Ku70/80 [49–51, 55], DNA-PKcs [51, 55]
	Polyomavirus simian virus 40	SV40	DNA-PKcs [60]
	Vaccinia virus	VACV	DNA-PKcs [62, 63], Ku70/80 [62, 63], Lig4 [65]
Group II: ssDNA viruses	Adeno-associated virus	AAV	DNA-PKcs [66–71], Lig4 [66], Ku70/80 [67, 68]
	Geminivirus	–	Ku80 [72]
	Parvovirus B19	B19	Ku80 [74]
Group IV: (+) ssRNA viruses	Hepatitis C virus	HCV	Ku70 [75]
Group VI: ssRNA-RT viruses	Avian sarcoma leukosis virus	ASLV	DNA-PKcs [76]
	Human immunodeficiency virus	HIV	DNA-PKcs [76, 79, 81–83, 85, 86], Ku80 [77, 78, 84, 85], Ku70 [80], Lig4 [81, 84, 85], XRCC4 [81, 85]
	Human T-cell leukaemia virus type	HTLV	Ku80 [88–90, 92], DNA-PKcs [91], Ku70 [92, 93]
	Mouse mammary tumour virus	MMTV	Ku70/80 [94]
Group VII: dsDNA-RT viruses	Hepatitis B virus	HBV	Ku70/80 [96]
	Duck hepatitis B virus	DHBV	Ku80 [98]