Table 4.
The result of the evaluation of candidate case definitions for type 1 diabetes
| Case definition | N (%)e | Performance values (95% CI) | ||
|---|---|---|---|---|
| Sensitivity | PPV | F-score | ||
| 1. ① ICD10 code of E10a | 305 (0.268) | 32.9 (28.4, 37.2) | 33.3 (28.0, 38.4) | 0.331 (0.285, 0.373) |
| 2. ② Claims code of injector needlesb | 154 (0.135) | 32.3 (27.9, 36.6) | 64.8 (58.9, 70.6) | 0.431 (0.382, 0.475) |
| 3. ③ Claims codes of basal insulinc | 1392 (1.224) | 40.2 (36.1, 44.5) | 8.9 (7.6, 10.3) | 0.146 (0.126, 0.166) |
| 4. ④ Claims codes of syringe pumpd | 14 (0.012) | 3.9 (1.9, 6.0) | 86.2 (68.0, 99.0) | 0.075 (0.037, 0.112) |
| 5. ① as well as ② | 73 (0.064) | 21.4 (17.0, 25.4) | 90.4 (85.0, 94.8) | 0.346 (0.286, 0.399) |
| 6. ① as well as ③ | 136 (0.120) | 25.9 (21.7, 30.1) | 58.8 (51.0, 66.2) | 0.360 (0.307, 0.411) |
| 7. ① as well as ④ | 12 (0.011) | 3.6 (1.7, 5.5) | 92.2 (79.0, 99.4) | 0.069 (0.034, 0.103) |
| 8. ① as well as (③ or ④) | 138 (0.121) | 26.4 (22.0, 30.5) | 58.9 (51.0, 66.2) | 0.364 (0.310, 0.414) |
| 9. ① as well as (② or ④) | 81 (0.071) | 23.7 (19.5, 27.9) | 90.2 (85.2, 94.4) | 0.375 (0.319, 0.427) |
| 10. ① as well as (② or ③) | 136 (0.120) | 25.9 (21.7, 30.1) | 58.8 (51.0, 66.2) | 0.360 (0.307, 0.411) |
| 11. ① as well as (② or ③ or ④) | 136 (0.120) | 26.4 (22.0, 30.5) | 58.9 (51.0, 66.2) | 0.364 (0.310, 0.414) |
CI confidence interval, NPV negative predictive value, PPV positive predictive value
aConfirmed disease name of type 1 diabetes based on ICD10 code
bThe claims code of injector needles for type 1diabetes
cThe claims codes of basal insulin
dThe claims codes of syringe pump for continuous subcutaneous insulin infusion
eNumber of cases who fell within the case definitions in the test data (prevalence within the test data)