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. 2021 Feb 11;19:13. doi: 10.1186/s12964-020-00647-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Icariside I promotes NLRP3 inflammasome activation stimulated by ATP and nigericin. a-c Caspase-1 activity (a) and ELISA of IL-1β (b), the release of LDH (c) in SN from LPS-primed BMDMs treated with various doses of Icariside I and then stimulated with ATP. (d) Western blots of SN and WCL from LPS-primed BMDMs treated with various doses of Icariside I and then stimulated with ATP. e Western blots of SN and WCL from LPS-primed BMDMs treated with various doses of Icariside I before nigericin stimulation. f-h Caspase-1 activity (f), ELISA of IL-1β (g) and the release of LDH (h) from LPS-primed BMDMs treated with various doses of Icariside I and then stimulated with nigericin. RLUs, the relative light units. Data are represented as the mean ± SD from at least three biological samples. ^##P < 0.01, ^###p < 0.001 vs. the control group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the LPS plus ATP or nigericin group