Table 4.
Pharmacokinetics parameters of Sahastara remedy extract capsules in healthy volunteers. Data presented as the mean ± SD, n = 12. Mann-Whitney U test has been used to statistically compared the data.
| Parameters | Sahastara (100 mg) | Sahastara (200 mg) | P-value |
|---|---|---|---|
| Cmax (ng/mL) | 3.77 ± 1.63 | 6.59 ± 2.86 | 0.008 |
| Tmax (h) | 2.15 ± 1.21 | 1.88 ± 1.19 | 0.160 |
| AUC0-48 (μg.h/mL) | 54.58 ± 21.00 | 77.73 ± 45.40 | 0.178 |
| AUC0-inf (μg.h/mL) | 58.41 ± 23.50 | 106.64 ± 87.07 | 0.178 |
| Mean residence time (h) | 16.76 ± 8.24 | 28.27 ± 34.38 | 0.590 |
| Half-life (h) | 8.74 ± 8.95 | 19.48 ± 29.53 | 0.977 |
Cmax, the maximum concentration of piperine; Tmax, time to reach the maximum concentration.