Supplemental Table 1.
Comparison of clinical, physiological, ventilator and outcome parameters using a PaO2:FiO2 ratio threshold of 100
| Parameter | Severe ARDS (n=115) | Very-severe ARDS (n=89) | P |
|---|---|---|---|
| Age, in years | 38.9±15.6 | 39.1±16.5 | 0.921 |
| Male gender, n (%) | 60 (52.2) | 51 (57.3) | 0.482 |
| Baseline APACHE II score | 20.5±8.7 | 23.1±8.7 | 0.038 |
| Ventilator and physiological parameters | |||
| Static compliance, mL/cm H20 | 23.1±9.7 | 23.1±9.6 | 0.998 |
| pH | 7.34±0.12 | 7.27±0.14 | <0.0001 |
| PaCO2, mmHg | 42.3±15.9 | 48.2±17.7 | <0.013 |
| PaO2:FiO2 ratio, mmHg | 123.6±13.4 | 72.7±19 | <0.0001 |
| Plateau pressure, cm H2O | 25.3±5.9 | 27.8±5.2 | <0.002 |
| PEEP, cm H2O | 8.5±2.9 | 11.5±4.7 | <0.0001 |
| Peak airway pressure, cm H2O | 29.1±7.9 | 33.1±6.5 | <0.0001 |
| Mechanical power, Joules/min | 25.8±9.8 | 28.6±9.4 | 0.088 |
| Outcome | |||
| ICU LOS, days | 10±9.4 | 10.8±10.5 | 0.572 |
| Hospital LOS, days | 16±14.2 | 13.9±13 | 0.286 |
| Death | 49 (42.6) | 43 (48.3) | 0.479 |
All values are described as mean±SD or n (%). APACHE II score: Acute physiology and chronic health evaluation score; ARDS: Acute respiratory distress syndrome; ICU: Intensive care unit; LOS: Length of stay; PaCO2: Partial pressure of carbon dioxide in arterial blood; PaO2:FiO2 ratio: Ratio of partial pressure of oxygen in arterial blood and fraction of oxygen in inspired air; PEEP: Positive end expiratory pressure, SD: Standard deviation