Table 3.
Perioperative risk factors contributing to postoperative delirium
| Preoperative factors | Intra- and postoperative factors |
|---|---|
| Age ≥65 years | Site of surgery (abdominal and cardiothoracic) |
| Multimorbidities (e.g. cerebrovascular including stroke, cardiovascular, peripheral vascular diseases, diabetes, anemia, Parkinson's disease, depression, chronic pain, and anxiety disorders) | Intraoperative bleeding (blood transfusion of >3 units) |
| Sensory impairment (hearing/visual loss) | Long duration of surgery |
| Higher American Society of Anesthesiologists’ physical status classification system or the Charlson Comorbidity Index (CCI) or the Clinical Impairment Assessment | Excessive pain |
| Score (CIAS) before surgery | |
| Frailty (malnutrition, hypoalbuminemia, hypercholesterolemia, high levels of inflammation, muscular atrophy, etc.) | Emergency surgery |
| Prolonged preoperative fluid fasting and dehydration | Postoperative complications |
| Hyponatremia/hypernatremia | Hyperthermia/Hypothermia |
| Anticholinergics | |
| Alcohol-related disorders/alcohol use disorders/substance abuse | |
| Cognitive impairment |