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. 2021 Jan 29;10:566804. doi: 10.3389/fonc.2020.566804

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Copyright © 2021 Chanukuppa, Taware, Taunk, Chatterjee, Sharma, Somasundaram, Rashid, Malakar, Santra and Rapole

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multivariate statistical analysis of MM serum vs. Control dataset using SWATH MS data. (A) OPLS-DA score plot for MM vs. Controls. (B) Dendrogram showing the hierarchical clustering between MM and controls based on DEPs. (C) Permutation test statistics of the OPLS-DA model of MM vs. Controls with Y-axis intercepts: R2 = (0.0, 0.924), Q2 = (0.0, −0.338), (D) V-Plot showing the most significant proteins in red circles. One sample in MM was removed from the SIMCA analysis as they had high degree of variation; hence the data shown is for eleven MM samples and twelve controls.