Table 1.

Partial list of differentially regulated BMIF proteins identified in MM.

Sr. No	UniProt ID	Protein Name	FC in DIGE	FC in iTRAQ	FC in SWATH	Molecular function	Biological process
1	P00738	Haptoglobin	1.78	1.51	1.55	antioxidant activity	Acute-phase response
2	P01857	Ig gamma-1 chain C region	2.49	5.84	0.45	antigen binding	B cell receptor signaling pathway
3	P01591	Ig J chain	1.69	5.70	20.27	antigen binding	adaptive immune response
4	P01871	Ig mu chain C region	0.28	6.65	15.71	antigen binding	adaptive immune response
5	P0DJI8	Serum amyloid A protein	2.38	1.89	—	chemoattractant activity	activation of MAPK activity
6	P01834	Ig kappa chain C region	—	9.49	4.98	antigen binding	B cell receptor signaling pathway
7	P01767	Ig heavy chain V-III region	—	3.13	2.34	antigen binding	complement activation
8	P00450	Ceruloplasmin	—	2.52	2.33	chaperone binding	cellular iron ion homeostasis
9	P00747	Plasminogen	1.57	—	2.29	apolipoprotein binding	blood coagulation
10	P04004	Vitronectin	2.25	—	1.63	collagen binding	cell adhesion
11	P01009	Alpha-1-antitrypsin	1.95	4.23	—	identical protein binding	acute-phase response
12	P01011	Alpha-1-antichymotrypsin	2.1	—	1.96	DNA binding	acute-phase response
13	P25311	zinc-alpha-2-glycoprotein	1.83	2.38	—	ribonuclease activity	transmembrane transport
14	P01042	Kininogen	3.94	—	2.82	endopeptidase inhibitor activity	blood coagulation, intrinsic pathway
15	P02768	Serum albumin	0.23	0.52	0.52	antioxidant activity	cellular protein metabolic process
16	P02675	Fibrinogen beta chain	0.34	0.36	—	chaperone binding	adaptive immune response
17	P80748	Ig lambda chain V-III region	—	0.67	0.54	antigen binding	complement activation
18	P01024	Complement C3		0.60	0.66	endopeptidase inhibitor activity	inflammatory response
19	P05452	Tetranectin	—	0.55	0.47	calcium ion binding	bone mineralization
20	P02786	Transferrin receptor protein 1	—	0.22	0.17	double-stranded RNA binding	cellular iron ion homeostasis
21	P02774	Vitamin D binding protein	0.25	—	0.64	actin binding	vitamin D metabolic process
22	P02787	Serotransferrin	0.38	—	0.42	ferric iron binding	actin filament organization
23	P02647	Apolipoprotein A-1	0.23	0.21	—	amyloid-beta binding	cellular protein metabolic process
24	P06396	Gelsolin	0.61	—	0.48	actin binding	actin filament capping