Table 2.
Partial list of differentially regulated serum proteins identified in MM.
| Sr. No | UniProt ID | Protein Name | FC in DIGE | FC in iTRAQ | FC in SWATH | Molecular function | Biological process |
|---|---|---|---|---|---|---|---|
| 1 | P00738 | Haptoglobin | 1.66 | 1.76 | 2.22 | Antioxidant activity | Acute-phase response |
| 2 | P01011 | Alpha-1-antichymotrypsin | 2.1 | 1.56 | 1.95 | DNA binding | Acute-phase response |
| 3 | P01042 | Kininogen 1 | 2.87 | — | — | Cysteine-type endopeptidase | Cellular protein metabolic process |
| 4 | P0DJI8 | Serum amyloid A-1 protein | — | 1.95 | 8.25 | Chemoattractant activity | Activation of mapk activity |
| 5 | P25311 | Zinc-alpha-2-glycoprotein | 1.83 | — | — | Glycoprotein binding | Cell adhesion |
| 6 | P01009 | Alpha-1-antitrypsin | 1.95 | — | — | Glycoprotein binding | Acute-phase response |
| 7 | P00450 | Ceruloplasmin | 2.16 | — | — | Chaperone binding | Iron ion homeostasis |
| 8 | P02763 | Alpha-1-acid glycoprotein 1 | — | 1.63 | 2.27 | — | Acute-phase response |
| 9 | Q06033 | Inter-alpha-trypsin inhibitor heavy chain H3 | — | 1.88 | 1.97 | Endopeptidase inhibitor activity | Hyaluronanmetabolic process |
| 10 | P01591 | Ig J chain | 4.38 | 3.30 | 1.66 | Antigen binding | Immune response |
| 11 | P61769 | Beta-2-microglobulin | — | 1.73 | — | Glycoprotein binding | Antibacterial humoral response |
| 12 | P43652 | Afamin | — | 0.38 | 0.61 | Vitamin E binding | Vitamin transport |
| 13 | P43251 | Biotinidase | — | 0.38 | 0.57 | Biotinidase activity | Biotin metabolic process |
| 14 | P29622 | Kallistatin | — | 0.30 | 0.54 | Serine-type endopeptidase | Platelet degranulation |
| 15 | P05452 | Tetranectin | 0.51 | 0.5 | Calcium ion binding | Bone mineralization | |
| 16 | P04004 | Vitronectin | 0.61 | 0.66 | — | Collagen binding | Cell adhesion |
| 17 | P02647 | Apolipoprotein A1 | 0.25 | 0.53 | — | Amyloid-beta binding | Adrenal gland development |
| 18 | P02787 | Serotransferrin | 0.38 | — | — | Ferric iron binding | Iron ion homeostasis |
| 19 | P01024 | Complement C3 | 0.43 | — | — | C5L2 anaphylatoxin chemotactic receptor binding | amyloid-beta clearance |
| 20 | P02774 | Vitamin D-binding protein | 0.38 | — | — | Actin binding | Vitamin D metabolic process |
| 21 | P02743 | Serum amyloid p component | 0.46 | — | — | Calcium ion binding | Acute-phase response |
| 22 | P06396 | Gelsolin | — | 0.56 | Actin binding | Actin filament capping | |
| 23 | P02768 | Serum albumin | 0.26 | — | 0.14 | Antioxidant activity | Bile acid and bile salt transport |