Table 1.

Univariate and multivariate analyses of baseline variables associated with deaths from infection versus deaths not due to infection.

Variable	Deaths from infection (%)	Deaths not due to infection (%)	Odds ratio	95% confidence levels	P-value
A. Univariate analysis: all trial patients with a known cause of death (n = 600)
≥2 lines of treatment	194/258 (75)	231/342 (68)	1.46	1.01–2.09	0.04
Winter season	149/258 (58)	166/342 (49)	1.45	1.05–2.01	0.03
BRAF mutation	19/175 (11)	9/225 (4)	2.92	1.29–6.63	0.01
FBXW7 mutation	8/175 (5)	2/225 (1)	5.34	1.12–25.48	0.04
NRAS mutation	9/175 (5)	1/225 (0.4)	12.14	1.52–96.79	0.02
XPO1 mutation	17/175 (10)	9/225 (4)	2.58	1.12–5.94	0.03
B. Univariate analysis: patients with a known cause of death and gene mutation data (n = 400)
11q deletion	47/162 (29)	40/209 (19)	1.73	1.06–2.80	0.03
BRAF mutation	19/175 (11)	9/225 (4)	2.92	1.29–6.63	0.01
FBXW7 mutation	8/175 (5)	2/225 (1)	5.34	1.12–25.48	0.04
NRAS mutation	9/175 (5)	1/225 (0.4)	12.14	1.52–96.79	0.02
XPO1 mutation	17/175 (10)	9/225 (4)	2.58	1.12–5.94	0.03
C. Multivariate analysis: patients with a known cause of death and gene mutation data (n = 400)
11q deletion			1.79	1.09–2.94	0.02
BRAF mutation			3.22	1.33–7.80	0.01
NRAS mutation			10.78	1.31–88.43	0.03
XPO1 mutation			2.49	1.01–6.12	0.05