Table 1.
Characteristics of patients who underwent transcatheter or surgical aortic valve replacement.
| Characteristics | TAVR 2130 patients |
SAVR 4333 patients |
p-Value |
|---|---|---|---|
| Age, mean (years) | 81.2 ± 6.6 | 75.1 ± 6.5 | <.0001 |
| Female, n (%) | 1172 (55.0) | 2026 (46.8) | <.0001 |
| Body mass index, mean (kg/m2) | 27.1 ± 4.8 | 27.7 ± 4.8 | <.0001 |
| Hemoglobin, mean (mg/L) | 125 ± 16 | 132 ± 15 | <.0001 |
| eGFR, mean (mL/min/1.73 m2) | 65 ± 23 | 76 ± 22 | <.0001 |
| Active malignancy, n (%) | 84 (3.9) | 60 (1.4) | <.0001 |
| Diabetes, n (%) | 605 (28.4) | 1154 (26.6) | .133 |
| Stroke, n (%) | 247 (11.6) | 299 (6.9) | <.0001 |
| Pulmonary disease, n (%) | 456 (21.4) | 642 (14.8) | <.0001 |
| Oxygen therapy, n (%) | 14 (0.7) | 16 (0.4) | .109 |
| Frailty GSS grades 2–3, n (%) | 318 (14.9) | 107 (2.5) | <.0001 |
| Extracardiac arteriopathy, n (%) | 412 (19.3) | 539 (12.4) | <.0001 |
| LVEF ≤50%, n (%) | 596 (28.0) | 909 (21.0) | <.0001 |
| Atrial fibrillation, n (%) | 932 (43.8) | 955 (22.0) | <.0001 |
| NYHA class 4, n (%) | 244 (11.5) | 453 (10.5) | .223 |
| SPAP, n (%) | <.0001 | ||
| 31–55 mmHg | 853 (40.0) | 1526 (35.2) | |
| >55 mmHg | 286 (13.4) | 305 (7.0) | |
| Moderate-severe mitral valve regurgitation, n (%) | 288 (14.3) | 256 (6.5) | <.0001 |
| Porcelain aorta, n (%) | 124 (5.8) | 15 (0.3) | <.0001 |
| Recent myocardial infarction, n (%) | 49 (2.3) | 312 (7.2) | <.0001 |
| Acute heart failure ≤60 days/critical preop. state, n (%) | 253 (11.9) | 501 (11.6) | .710 |
| Coronary artery disease, n (%) | 603 (28.3) | 1970 (45.5) | <.0001 |
| Prior PCI, n (%) | 467 (21.9) | 405 (9.3) | <.0001 |
| Prior cardiac surgery | 431 (20.2) | 97 (2.2) | <.0001 |
| Permanent pace-maker, n (%) | 208 (9.8) | 174 (4.0) | <.0001 |
| Emergency procedure, n (%) | 6 (0.3) | 59 (1.4) | <.0001 |
| Bicuspid aortic valve, n (%) | 114 (5.4) | 920 (21.0) | <.0001 |
| Concomitant PCI/CABG, n (%) | 119 (5.6) | 1835 (42.3) | <.0001 |
| EuroSCORE II, mean (%) | 7.2 ± 7.4 | 4.2 ± 5.5 | <.0001 |
| STS Score, mean (%) | 4.6 ± 3.3 | 3.0 ± 2.9 | <.0001 |
Continuous variables are reported as means ± standard deviation. Categorical variables as counts and percentages. Clinical variables are according to the EuroSCORE II definition criteria. SAVR: surgical aortic valve replacement; TAVR: transcatheter aortic valve replacement; eGFR: glomerular filtration estimated according to the MDRD equation; LVEF: left ventricular ejection fraction; Frailty, GSS grades 2–3; SPAP: systolic pulmonary artery pressure; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting.