Figure 1.

Molecular characteristics and clinical relevance of m⁶A regulators in ccRCC. (A) The mutation frequency of m⁶A regulators in ccRCC. (B) Dumbbell plot depicted the CNV alteration frequency of m⁶A regulators in ccRCC. The deletion (amplification) frequency was marked with blue (red) dot. (C) The gene expression alterations among m⁶A regulators. (D) Interaction of m⁶A regulators in ccRCC. Readers, yellow; Writers, blue; Erasers, red. The size of each circle represented survival impact of each m⁶A regulator, calculation used the formula log10 (unicox p values indicated). Green (black) dots represented favorable (risk) factors of overall survival. The lines connecting m⁶A regulators presented their interactions, and thickness of the lines represented the correlation strength among regulators. Positive (negative) correlation was indicated in red (blue). ccRCC, clear cell renal cell carcinoma; CNV, copy number variation; m⁶A, N6-methyladenosine; OS, overall survival.