Table 2.

Clinical features of patients with OPN with autoimmune diseases vs. optic neuritis.

	OPN	ON	p
Number of patients (n)	33	61
Number of eyes associated with disease (n)	59	78
Sex ratio (M/F)	19/14	25/36	0.124
Median age, years (mean ±SD)	54.21 ± 17.10	44.56 ± 14.59	0.004**
Bilateral involvement, n (%)	26 (78.79%)	17 (27.87%)	0.000**
Acute onset, n (%)	12 (36.36%)	61 (100%)	0.000**
Visual Acuity, (LogMar score)	0.55 ± 0.91	1.19 ± 1.24	0.000**
Ptosis, n (%)	11 (33.33%)	0 (0%)	0.000**#
Diplopia, n (%)	9 (27.27%)	0 (0%)	0.000**#
Exophthalmos, n (%)	10 (30.30%)	0 (0%)	0.000**#
Connective tissue disease, n (%)	33 (100%)	7 (11.48%)	0.000**#
MS	0 (0%)	8 (13.11%)	0.040#
NMOSD	0 (0%)	7 (11.48%)	0.040*#

MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorders.

^*p < −0.05,

^**p < 0.01,

^#isher's exact test.