Table 3.
The percentage of UV relative abundance of metabolites of compound 12in RLMs supplemented with NADPH
| Met/Parent | Modification | RT in MS (min) | UV % relative abundancea | M+H |
|---|---|---|---|---|
| 12 | 10.54 | 6.2 | 385.2317 | |
| Met 1 | N-dealkylation | 5.72 | MSb | 166.1590 |
| Met 2 | P+2O | 6.54 | 1.4 | 417.2206 |
| Met 3 | N-demethylation+2O | 6.60 | 5.1 | 403.2050 |
| Met 4 | P+2O | 6.78 | 9.4 | 417.2206 |
| Met 5 | N-demethylation+2O | 7.03 | 7.1 | 403.2050 |
| Met 6 | P+2O-2H | 7.30 | 28.6 | 415.2050 |
| Met 7 | N-demethylation+2O-2H | 7.39 | 1.7 | 401.1893 |
| Met 8 | N-demethylation+2O-2H | 7.61 | 4.3 | 401.1893 |
| Met 9 | N-demethylation+O | 8.01 | 1.2 | 387.2101 |
| Met 10 | N-demethylation+O | 8.25 | 27.2 | 387.2101 |
| Met 11 | P+O | 8.35 | 2.5 | 401.2257 |
| Met 12 | N-demethylation+O | 8.62 | 2.7 | 387.2101 |
| Met 13 | P+O | 8.77 | 2.7 | 401.2257 |
| Met 14 | N-demethylation+O −2H | 385.1944 |
a
UV wavelength = 249 nm.
b
Peak detected in mass detector only.