Table 7.
The registered clinical trials of treatment using EVs or exosomes derived from MSCs
| NCT number | Title | Status | Condition | Phase | Start date |
|---|---|---|---|---|---|
| NCT04173650 | MSC EVs in Dystrophic Epidermolysis Bullosa | Not yet recruiting | Dystrophic Epidermolysis Bullosa |
Phase 1 Phase 2 |
Sep-2020 |
| NCT04276987 | A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia | Completed | Coronavirus | Phase 1 | Feb-2020 |
| NCT02138331 | Effect of Microvesicles and Exosomes Therapy on cell Mass in Type I Diabetes Mellitus (T1DM) | Unknown status | Diabetes Mellitus Type 1 |
Phase 2 Phase 3 |
Apr-2014 |
| NCT04313647 | A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers | Recruiting | Healthy | Phase 1 | Mar-2020 |
| NCT03384433 | Allogenic Mesenchymal Stem Cell-Derived Exosome in Patients With Acute Ischemic Stroke | Recruiting | Cerebrovascular Disorders |
Phase 1 Phase 2 |
Apr-2019 |
| NCT04223622 | Effects of ASC Secretome on Human Osteochondral Explants | Not yet recruiting | Osteoarthritis | - | Feb-2020 |
| NCT04213248 | Effect of UMSCs-Derived Exosomes on Dry Eye in Patients With cGVHD | Recruiting | Dry Eye |
Phase 1 Phase 2 |
Feb-2020 |
| NCT03437759 | MSC-Exos Promote Healing of MHs | Recruiting | Macular Holes | Early Phase 1 | Mar-2017 |
| NCT04356300 | Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfunction Syndrome After Surgical Repair of Acute Type A Aortic Dissection | Not yet recruiting | Multiple Organ Failure | Not Applicable | Sep-2020 |
| NCT04388982 | The Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease | Recruiting | Alzheimer Disease |
Phase 1 Phase 2 |
Jul-2020 |
| NCT03608631 | Exosomes in Treating Participants with Metastatic Pancreas Cancer with KrasG12D Mutation | Not yet recruiting | Metastatic Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Stage IV Pancreatic Cancer | Phase 1 | Mar-2020 |
| NCT04602442 | Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia | Enrolling by invitation | Covid19 | Phase 2 | Oct-2020 |
| NCT04491240 | Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia | Completed | Covid19 |
Phase 1 Phase 2 |
July 2020 |
| NCT04602104 | A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS | Not yet recruiting | Acute Respiratory Distress Syndrome |
Phase 1 Phase 2 |
Oct-2020 |
| NCT03857841 | A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD | Recruiting | Bronchopulmonary Dysplasia | Phase 1 | June-2019 |