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Recent insights into glial engulfment across species in the contexts of development. In zebrafish, IL-1β triggers neural crest cells to phagocytose neuron debris during development. Microglia in the mouse CNS recognize PS as an “eat me” signal to initiate phagocytosis through the opsonin C1q and likely various receptors, including TREM2. Top, Magenta represents cellular source of ligand. Bottom, Green represents engulfing cell. ?, Indirect evidence.
