Figure 3.

Schematic diagram LLPS at synapses. Synapses contain various unique biological condensates, such as active zones and PSD. In a presynaptic bouton (light blue), the reserve pool of synaptic vesicles (SV) can form molecular condensates via coacervating with the synapsin condensates. The docked pool of synaptic vesicles instead coats the surface of active zone condensates formed by proteins, including RIM, RIM-BP, and ELKS. In the postsynaptic neuron (purple) and both in excitatory and inhibitory synapses, formation of PSD assemblies may also involve phase separation of synaptic scaffold proteins interacting with neurotransmitter receptors.