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Npas2 mutants have a greater propensity to self-administer cocaine. A, An Npas2 mutation increased the propensity to self-administer cocaine, decreasing the days required to reach acquisition criteria, during the light phase. B, Total cocaine intake was also increased in mutant mice during the light phase. C, D, In the dark phase, these effects were selective to females. Mean + SEM; individual data points are shown, *p < 0.05, ***p < 0.001, n = 10–19.
