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Schematic model of how chondroitinase and antidepressant treatments promote plasticity by releasing TRKB from dephosphorylating control of PTPσ. Left, In the presence of PNNs, active PTPσ dephosphorylates TRKB and suppresses its signaling. Middle, In the absence of PNNs, PTPσ is inactive and pTRKB is facilitated. Right, Fluoxetine (FLX) disrupts TRKB:PTPσ interaction, promoting TRKB signaling.
