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. 2021 Feb 15;131(4):e139496. doi: 10.1172/JCI139496

Figure 4. SCFA-rich diet ameliorates lipid handling defects in K15-SKO mice.

Figure 4

(A) Schematic of prevention study pertaining to panels B–D depicting 8 weeks on either normal chow (NC) or SCFA-enriched diet followed by IPGTT/IPITT assessment. (B) Body weight of K15-SKO mice fed either NC or SCFA diet throughout 8 weeks of diet (n = 7–8). (C) IPGTT and (D) IPITT of K15-SKO mice fed either NC or SCFA (n = 5–7). (E) Schematic of therapy study pertaining to panels F–H depicting 5 weeks on HFD with IPGTT/IPITT, followed by 8 weeks of either NC or SCFA diet and IPGTT/IPITT. (F) Body weight of K15-SKO mice fed 5 weeks of HFD followed by NC or SCFA diet for an additional 8 weeks (n = 9–10). (G) IPGTT and (H) IPITT after 5 weeks of HFD and after an additional 8 weeks of NC or SCFA diet (n = 6–11). Data represent mean ± SEM. Comparisons between groups for panels B–D and F were performed using an unpaired, 2-tailed Student’s t test, *P < 0.05, **P < 0.01, ***P < 0.001. Comparisons between groups in panels F–H were performed using 1-way ANOVA with Tukey’s post hoc test, *P < 0.05 compared with HFD, #P < 0.05 compared with HFD+NC.