Table 1. Effects of cannabis cultivars on the levels inflammation and fibrosis-related genes human 3D EpiDermFT tissues, as studied by the global transcriptome profiling using RNAseq.
| LINE | #4 | #8 | #14 | #13 | #6 | #12 | #15 |
| Inflammation- and fibrosis-related genes | |||||||
| TNF | -3.4 | -3.6 | -4.4 | -2.9 | -3.9 | ||
| IL1A | -1.6 | -1.4 | -1.8 | -1.7 | -1.6 | ||
| IL1B | -4.0 | -3.6 | -2.4 | ||||
| IL6 | -2.0 | -1.8 | -2.8 | -2.4 | 1.3 | ||
| IL17C | -3.5 | -7.4 | |||||
| IL20 | -4.8 | -4.4 | -3.2 | ||||
| IL23A | -5.6 | -5.2 | -6.7 | -6.0 | -6.3 | 1.3 | |
| IL24 | -1.2 | -1.1 | |||||
| IL32 | -2.0 | -1.5 | -2.7 | 3.2 | |||
| IL33 | -1.0 | -1.0 | |||||
| IL37 | -8.4 | ||||||
| CCL2 | -2.5 | -1.6 | -3.1 | -2.7 | |||
| CCL20 | -4.2 | -3.3 | -5.7 | -4.2 | |||
| CXCL1 | -2.1 | -1.4 | |||||
| CXCL2 | -2.9 | -2.0 | -3.5 | -2.8 | |||
| CXCL3 | -3.8 | -3.3 | |||||
| CXCL5 | -3.9 | -3.0 | -4.0 | ||||
| CXCL6 | -1.8 | -1.2 | -1.3 | ||||
| CXCL8 | -4.1 | -3.5 | |||||
| CXCL10 | 2.3 | ||||||
| CXCL12 | 3.8 | 3.2 | |||||
| CXCL14 | 5.0 | ||||||
| NFKB2 | -1.0 | -1.1 | -1.5 | -1.1 | |||
| PTGS2 | -3.3 | -2.5 | -3.7 | -2.9 | -3.3 | 1.6 | |
| TLR2 | -1.8 | -1.2 | -2.0 | ||||
| Fibrosis-related genes | |||||||
| MMP1 | -2.7 | -1.8 | |||||
| MMP3 | -1.8 | ||||||
| MMP7 | 2.7 | 3.6 | 2.8 | ||||
| MMP8 | -1.5 | -2.0 | |||||
| MMP10 | -1.7 | -1.7 | -1.5 | ||||
| MMP11 | 3.2 | 2.9 | |||||
| MMP19 | -1.0 | -1.1 | |||||
| WNT2 | -2.2 | -1.5 | -2.1 | -1.5 | -2.2 | ||
| WNT5A | -1.5 | -1.2 | -1.5 | -1.4 | -1.3 | ||
| FZD4 | -1.2 | ||||||
| ICAM1 | -1.5 | -1.4 | -2.2 | -1.8 | |||
| ICAM5 | -1.6 | -2.0 | |||||
Data are shown as log 2 fold changes as compared to UV-induced tissues. All changes shown here are statistically significant, p adj <0.05, ANOVA-like analysis and pair-wise comparison.