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. 2020 Dec 9;13(2):2198–2211. doi: 10.18632/aging.202234

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Copyright: © 2021 Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Effects of circ_0005198 expression on the progression of TMZ-resistant glioma cells. (A) qRT- PCR analysis of circ_0005198 expression in transfected U138/TMZ and LN18/TMZ cells. (B) The viability of U138/TMZ and LN18/TMZ cells transfected with si-circ_0005198-2 were detected by CCK-8 assay. (C) The proliferative rate of transfected U138/TMZ and LN18/TMZ cells was determined by colony formation assay. (D) The apoptotic rate of cells was determined using flow cytometry after circ_0005198 knockdown in U138/TMZ and LN18/TMZ cells. (E) CCK-8 assay was performed to measure the TMZ resistance of U138/TMZ and LN18/ TMZ cells. *P <0.05, **P < 0.01, *‘*P < 0.001.