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. 2020 Dec 9;13(2):2198–2211. doi: 10.18632/aging.202234

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Copyright: © 2021 Deng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Circ 0005198 targeted miR-198. (A) qRT-PCR showed the enrichment of circ_0005198 in cytoplasmic. (B) The predicted binding sites between circ_0005198 and miR-198. (C) MiR-198 expression in U138/TMZ and LN18/TMZ cells was detected by qRT-PCR after transfection with miR-138 mimic. (D) Luciferase reporter assay was performed for the confirmation of direct binding relationship between circ_0005198 and miR-198 with luciferase reporter plasmids of wild-type and mutant circ_0005198. (E) qRT-PCR was performed to detect the effect of circ_0005198 on miR-198 expression. (F) Enrichment of circ_0005198 and miR-198 using Ago2 antibody in U138/TMZ and LN18/TMZ cells was tested by RIP assay. **P < 0.01, ***P < 0.001.